How it Works: Chronic Nerve Pain

 

THC:

5 mechanisms involved with pain reduction with CB1 and CB2 activation by THC

 

• Retards electrochemical reactions at peripheral pain receptors.
  
• Interrupts pain signal at dorsal root ganglion.
  
• Interrupts pain signal at neuron.
  
• Activation of CB2 at microglial cells provides major anti-inflammatory response.
  
• Psychoactive euphoric effects and short term memory reduction mitigate stress response to pain.
  

 

CBD:

Anti-inflammatory mechanism provides 30-50 times hydrocortisone relief without shutting down adrenal gland.

 

    

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Courtesy Dr. Cristina Sanchez, Complutense University

 

 

    

 

 

• EUPHORIA
  

 

 

• SHORT TERM MEMORY REDUCTION
  

 

Mood control areas

 

 

 

Memory control areas

 

CB1

 

 

CB1

CB2

 

 

 

• REDUCED INFLAMMATION
  

 

CB1

Pain perception areas

 

 

 

 

 

Epithelial cells

CB1

 

• REDUCED
  

 

(kidneys, skin, lungs, etc.)

CB1

PAIN PERCEPTION

 

 

 

 

 

Joints

CB1

 

 

GI tract

 

 

CB1

CB1

CB2

 

 

Dorsal root ganglia

 

Courtesy Dr. Cristina Sanchez, Complutense University

 

Reduction in Pain Drugs Prescribed in Legal Cannabis States

 

 

Medical Marijuana Laws Reduce Prescription Medication Use In Medicare Part D http://content.healthaffairs.org/content/35/7/1230

 

Which Cannabinoid to Choose?

 

How Much to Take?

THC ~ 15mg x 2 per day

CBD ~ 20mg x 1 per day

TOPICAL    ~ 10mg x 3 per day